A comedy special, Marc Maron: Too Real, was released on Netflix on September 5, 2017.From almost the first day of the liberal talk radio network Air America's broadcasts in 2004, Maron co-hosted Morning Sedition, a three-hour early-morning radio show with Mark Riley that aired weekdays from 6 am to 9 am Eastern time.The show was unique in the Air America lineup in its heavy reliance on both live and preproduced sketch comedy, utilizing the talents of staff writers as well as the on-air hosts.

In the summer of 2017, he began a co-starring role in the Netflix comedy, GLOW, where he plays a sleazy C movie director put in charge of creating a women's professional wrestling show out of a group of female misfits. When his father left the Air Force, he moved his family to Albuquerque, New Mexico, and started a medical practice.

He later moved to New York City and became part of the New York alternative comedy scene.

He is particularly known for relentless on-stage exploration of his own relationships with family, girlfriends, and other standup comedians that he has known and befriended over his many years in the business.

In 2012, he provided the voice of Magnus Hammersmith in three episodes of Metalocalypse.

Maron has made two guest appearances as himself on Louis C.

K.'s show Louie, first in the third season episode Ikea/Piano Lesson The show is loosely autobiographical, revolving around Maron's life as a twice-divorced sober comedian running a comedy podcast out of his garage but establishing many differences between the real-life Maron and the version of him on TV.

Maron and Seder held court in an online "post-show chat" with viewers, in an even less formal continuation of each webcast, after the credits had rolled.

Maron's standup comedy act is marked by his commitment to self-revelation and cultural analysis.

On November 28, 2005, it was officially announced that Maron's contract had not been renewed.